Ana Teixeira | Senior Researcher & Group Leader
I have a degree in Chemical Engineering from the Instituto Superior Técnico, Lisbon, and a PhD from the University of Wisconsin-Madison, USA, in Chemical and Biological Engineering, with Prof. Paul Nealey as an advisor. Between 2003 and 2007, I did a post-doc at Karolinska Institutet in the lab of Dr. Ola Hermanson on neural stem cell biology. In the fall of 2008 I became a group leader at Karolinska Institutet. In January 2015 we became one of the founding groups of the division of Biomaterials and Regenerative Medicine at the department of Medical Biochemistry and Biophysics.
Email Address: Ana.Teixeira@ki.se
Alessandro Bosco | Postdoctoral Reseacher
I have a master degree in material science and engineering and a PhD in Physics and Chemistry of Biological Systems and my main project in the group is focused on understanding the role of the biophysical context at the cell-cell interface in membrane receptor clustering. Different techniques, ranging from DNA nanotechnology to Atomic Force Microscopy via standard biochemical techniques and computational tools are used to picture a mechanism for the formation of the signalling assembly and to understand the specificity of the signalling induced by the spatial distribution of the ligands.
Email Address: Alessandro.Bosco@ki.se
Trixy Fang | PhD Student
I am a PhD student studying spatial regulation in the immunological synapse. In particular, I am interested in the spatio-mechanics of programmed-cell-death-1 protein (PD-1) inhibition on T cell activation in cancer immune evasion and how nanoscale spatial organization of PD-1 and T cell receptor/CD3 regulates T cell receptor activation and signalling.
Email Address: Trixy.Fang@ki.se
Hannah Litwin | PhD Student
I received my MSc in Biomedicine at Karolinska institutet (2014) and continued as a PhD student in the Teixeira lab afterwards. My overall research goal is to investigate the role of nanoscale spatial distribution of membrane bound ligands and receptors in regulating cell-to-cell communication. I am particularly interested in the Notch signalling pathway in the context of cancer biology and neural development. To address this question I am using DNA origami fabricated nanostructures decorated with proteins to control the receptor/ligand distribution on the cell membrane at the nanoscale. This is combined different cell culture techniques and cell biology based assays.
Email Address: Hannah.Litwin@ki.se
Toon Verheyen | Postdoctoral Researcher
I received my PhD in Biomedicine at the Catholic University of Leuven (2014) and joined the Teixeira group shortly afterwards. My research goal is to investigate the nano-spatial distribution of membrane receptors, with particular interest in the EphA2 receptor. My interest lies in the effect this distribution has on the downstream signaling cascades and subsequent gene expression. To study these questions, I combine the DNA origami technique with cell biology-based assays as well as bioinformatical analysis.
Email Address: Toon.Verheyen@ki.se
Christina Kolonelou | PhD Student
Ι received my MSc in Molecular Medicine from Uppsala University before I joined the Teixeira lab. My research interests focus on the roles of mechanotransduction in cell communication and specifically how biophysical signals encoded in the spatial distribution of membrane proteins and in applied tension forces impact cellular behaviors.
Email Address: firstname.lastname@example.org
Elena Ambrosetti | Postdoctoral Researcher
I have a master degree in Biotechnology and Biocatalysis and a PhD in Nanotechnology. During my PhD I focused my studies on the characterization of innovative binders for the development of an Atomic Force Microscopy-based Nanoarray for the detection of cancer biomarkers, with particular interest in Her2 receptor. I also studied Her2 co-localization with specialized membrane microdomains, the dimerization and the shedding process involved in cancer progression. In 2017 I joined the Teixeira group where I have started a postdoc position. Here my research is focused on the characterization of spatial signaling of protein clusters in the membrane, by means of different biophysical techniques combined with DNA nanotechnology. The aim is to understand how the distribution and the clusters formation of membrane receptors influence the protein function, the signaling and the cell outcome.
Email Address: Elena.email@example.com
Hermes Taylor-Weiner | Postdoctoral Researcher
I received my Bachelor's degree in bioengineering from Olin College in Needham, Massachusetts. I then attended a doctoral program in the department of bioengineering at the University of California, San Diego. During my PhD I studied how extracellular matrix signaling regulates embryonic stem cell differentiation during early development. In general, I am interested in how the biophysical and biochemical properties of the microenvironment can affect cell behavior. I am also interested in the intersection between science and policy and have published a brief about unregulated stem cell clinics in the United States. I am now living in Stockholm and have started a postdoc position with funding from the Whitaker Scholars program.
Email Address: firstname.lastname@example.org
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